66 | December 2021 www.facs.website Figure 2. (A) 6p-azaelectrocyclization reaction mechanism from the cyclization of 1-azatrienes to 1,2-dihydropyridine. (B) Applications of the RIKEN click reagent for protein labeling in a number of targeted scaffolds. (C) Preparation of 67Cu-, or 211At-labled radiotherapeutics via a one-pot reaction using the RIKEN click reagent, tetrazine-linked metal chelator, and targeting antibody. In vivo data reveals effective accumulation and suppression of tumor growth. (D) Artificial glycosylated lymphocytes used to study glycandependent changes to lymphocyte trafficking. Organs of interest are the spleen (SP), lymph node of the epidermal intestinal tract (LN), and implanted DLD-1 tumor (TN). (E) Artificial glycosylated cancer cells used to study glycan-dependent changes to metastasis. I) Effects of polylactosamine in MKN45-related metastasis. II) Effects of fucosylation in HCT116-related metastasis.
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