| 19 | "Today, to make progress towards the establishment of in vitro models like organs-on-chips, we need to combine these tools from engineering and biology," Yadid reflected, underscoring the vital fusion that drives her research today. Cardiovascular Research and Organ-on-Chip Technology Yadid's work is deeply connected to the cardiovascular system and its complex interaction with other organs. Endothelial cells, which line blood vessels, play a crucial role in regulating tissue function and metabolism, but their dysfunction can lead to a range of diseases. "The heart is not just a regular pump. It's an adaptive pump,” she explained. “The mechanisms of how the body controls or regulates the heart's activity and the vessels' compliance is intriguing." Organs-on-chips play a central role in Yadid’s lab, serving as a revolutionary tool to simulate human organ systems on a microscale. These models are created using human cells and engineered materials, mimicking the structure and function of organs. Her team, for example, has developed heart and muscle-on-chip models equipped with embedded sensors to monitor tissue function in real time. "We have a human heart on a chip, with human heart cells forming tissue that mimics natural heart contractions—it's literally beating in the dish." “We use this to measure the mechanical functions of the heart”. Healthy (left) and diabetic (right) endothelial cells
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