| 20 | 2024 Annual Report She describes how these engineered heart tissues mimic the electrical and mechanical properties of native heart tissue, offering an unprecedented tool for studying drug toxicity and therapeutic interventions without relying on animal models. “We use this to measure the mechanical functions of the heart,” she explained. Extracellular Vesicles and Nanotechnology Yadid’s research also delves into extracellular vesicles (EVs)—tiny particles that cells release into bodily fluids such as blood and urine. These vesicles facilitate cell-to-cell communication by carrying biomolecules like proteins, lipids, and nucleic acids, playing a role in various physiological and pathological processes. Yadid’s lab focuses on the impact of EVs derived from blood vessels, particularly those from endothelial cells on cellular homeostasis, metabolism, and stress responses. The nanoscale nature of EVs makes them especially relevant to nanotechnology, which is crucial for their manipulation and study. Her work connects biology and nanotechnology, focusing on human health at the molecular and cellular levels. "One of the main focuses of my lab is understanding how vascular tissues—the blood vessels—serve as the common link between different organs and facilitate communication among them. All blood vessels are interconnected." Engineered human heart tissue
RkJQdWJsaXNoZXIy NDU2MA==