2024 ANNUAL REPORT

| 59 | Publications 2023 and 2024 • Saja Nasser, Gili Cohen-Taguri, Tali Mass, Iddo Pinkas, Gil Goobes. “Analysis of Ca1-xSrxCO3 Phases Generated by Competitive Sr2+ Replacement in Preformed Aragonite.” Heliyon, 2024. • Ortal Breuer, Ido Rozen, Nicole Leifer, Gayathri peta, Miryam Fayena-Greenstein, Doron Aurbach, Gil Goobes. “A Novel Approach for Post-Mortem Analysis in All-Solid-State Batteries: Isolating Solid Polymer Electrolytes from Lithium Anodes.” Journal of The Electrochemical Society, 2024. • Vincent Otieno Ayieko, Lilian Cohen, Sabrina Diehn, Gil Goobes, Rivka Elbaum. “Siliplant1 B-Domain Precipitates Silica Spheres, Aggregates, or Gel, Depending on Si-Precursor to Peptide Ratios.” Colloids and Surfaces B: Biointerfaces, 2023. • Gil Goobes, Perunthiruthy K Madhu, Amir Goldbourt. “Remembering Shimon Vega: Special Issue on Solid-State and DNP NMR.” Solid State Nuclear Magnetic Resonance, 2023. • Yajie Liu, Zhixin Tai, Ido Rozen, Zhipeng Yu, Ziyu Lu, Alec P LaGrow, Oleksandr Bondarchuk, Qingqing Chen, Gil Goobes, Yi Li, Lifeng Liu. “Ion Flux Regulation through PTFE Nanospheres Impregnated in Glass Fiber Separators for Long‐Lived Lithium and Sodium Metal Batteries.” Advanced Energy Materials, 2023. • Irina Matlahov, Alex Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes. “Selective Excitation with Recoupling Pulse Schemes Uncover Properties of Disordered Mineral Phases in Bone-Like Apatite Grown with Bone Proteins.” Solid State Nuclear Magnetic Resonance, 2023. Dr. Hamo Asaf Department of Physics The Lab for Quantum Imaging Research Areas • Quantum sensors • Diamond • Nitrogen Vacancies (NV) Abstract The lab is focused on using quantum sensors to image various physical properties at the nanoscale. The two main sensors are a sensor for electric potentials based on carbon nanotubes and a sensor for magnetic fields based on Nitrogen Vacancies (NV) in diamonds. Those sensors have a unique combination of small dimensions and extremely high sensitivity, allowing us to use them for sensing minute fields at the nanoscale. The current projects focus on combining these two unique sensors to overcome many of the limitations of each system. For example, read the NV center’s quantum state using a charge detector made of a carbon nanotube. A second example is using the NV center to probe the electron state on the carbon nanotube with quantum coherence. These projects will pave the way for a quantum imaging technique that probes the quantum nature of a system at the nanoscale. Proposed imaging system of orbital moment of a single electron. A carbon nanotube is suspended between two metallic contacts and above a few metallic gates. A small quantum dot is formed in the center of the carbon nanotube and is populated with a single electron. The electron will circulate clockwise or anti-clockwise depending on the external magnetic field. A diamond tip with a single NV center is brought few tens of nanometers away from the quantum dot. Publications 2023 and 2024 • Dominik Szombathy, Miklós Antal Werner, Cătălin Paşcu Moca, Örs Legeza, Assaf Hamo, Shahal Ilani, Gergely Zaránd. “Collective Tunneling of a Wigner Necklace in Carbon Nanotubes.” Physical Review B, 2024. Prof. Hendel Ayal The Mina & Everard Goodman Faculty of Life Sciences Precise and Efficient CRISPR Genome Editing As a Curative Therapy for Genetic Disorders Research Areas • Biotechnology • Genetic therapy • Genetic engineering • Developing CRISPR technology as a method of gene therapy for genetic diseases Abstract We are in the midst of a revolution in genome editing, and CRISPR-Cas9 technology was the spark for this. With unprecedented rapidity, this technology has provided a straightforward, robust, and specific method for genome editing. Our research focuses on developing genome editing as curative therapy for genetic diseases. Our lab is particularly interested in applying genome editing for gene therapy of hematopoietic genetic disorders such as severe combined immunodeficiency (SCID). SCIDs are a set of life-threatening genetic diseases in which patients are born with mutations in single genes and are unable to develop functional immune systems. While allogeneic bone marrow transplantation can be curative for these disorders, there remain significant limitations to this approach. We believe the ultimate cure for these diseases will be the transplantation of gene-corrected autologous CD34+ hematopoietic stem and progenitor cells (HSPCs). To apply this approach in the clinic, we must ensure that the genomeediting technology is efficient and safe. Hence, our research focuses on developing an optimized CRISPR-genome editing for robust, site-specific, and non-toxic functional gene correction in HSPCs. Another aspect of our research focuses on applying the CRISPR technology to treat malignancies using cancer immunotherapy.

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