2024 ANNUAL REPORT

| 63 | expected to lead to a breakthrough in the speed and energy cost of computations needed for artificial intelligence, particularly impacting applications that require computational capabilities at the Edge, such as in transportation, medicine, robotics, and more. The research team will develop such a device based on Spintronics - a field focused on studying physical phenomena related to the fact that, in addition to its electric charge, an electron also possesses a magnetic moment called spin. The Spintronic component, which will be the heart of the new device, is a magnetic tunnel junction where a thin insulating layer separates two magnetic layers. The resistance of the magnetic tunnel junction depends on the relative alignment of magnetizations in the two layers: It's low when the magnetizations in both layers are parallel and high when they are opposed. Commonly used magnetic tunnel junctions support only parallel and opposed states. However, when the components of the analog device have only two resistance states, its usefulness for artificial intelligence purposes is severely limited. Therefore, the analog device the team will develop and fabricate will be based on novel magnetic tunnel junctions that support a larger number of magnetic states, greatly enhancing the analog device's precision, speed, and energy efficiency. The group will work together for approximately three years to develop and fabricate an initial prototype of a device and prove its usefulness and efficiency. Such hardware will be essential for Edge computing, where it's crucial for computations to be performed near the data source obtained, for example, through various sensors. Such applications include autonomous vehicles, real-time analysis of security camera footage, urgent medical procedures requiring immediate decisions, and more. For more details, see https:// multispinai.eu/ A flexible planar Hall effect sensor. Publications 2023 and 2024 • Proloy T Das, Hariharan Nhalil, Vladislav Mor, Moty Schultz, N Hasidim, Asaf Grosz, Lior Klein. “Two-Axis Planar Hall Magnetic Field Sensors with Sub NanoTesla Resolution.” IEEE Transactions on Magnetics, 2024. • Daniel Lahav, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “Planar Hall Effect Magnetic Sensors with Extended Field Range.” Sensors, 2024. • Julian Schütt, Hariharan Nhalil, Jürgen Fassbender, Lior Klein, Asaf Grosz, Denys Makarov. “Modular Droplet‐Based Fluidics for Large Volume Libraries of Individual Multiparametric Codes in Lab‐On‐Chip Systems.” Advanced Sensor Research, 2023. • Hariharan Nhalil, Daniel Lahav, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “Flexible Planar Hall Effect Sensor with Sub-200 pT Resolution.” Applied Physics Letters, 2023. • Hariharan Nhalil, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “Parallel Array of Planar Hall Effect Sensors for High-Resolution Magnetometry.” Journal of Applied Physics, 2023. Prof. Lellouche Jean-Paul Department of Chemistry Innovative Surface Engineering of Magnetic/Non-Magnetic Nanomaterials Research Areas • Functional electroconductive polymers (ECPs) and nano/microparticle fabrication - Functionalization/nanostructuration of polymeric films • Magnetically-responsive composite polymer nanoparticles for ultrasensitive detection of DNA hybridization and drug release using combinatorial approaches • ECPs-microarrays for diagnostics • ECPs-biosensors/immunosensors • High-throughput screening of polymersupported chiral catalysts • (1,3)-dienyliron-carbonyl complexes in asymmetric synthesis • Selective deprotective chemistries of-OSiR3 ethers mediated by VilsmeierHaack reagents (kinetic resolutions/ deracemizations of meso compounds). • Functionalization of carbon nanotubes and use in self-assembling systems/ composite materials • Polymodal silica and silicon carbide nanoparticles for hard surfaces and their mode of functionalization using ECPs Abstract Prof. Lellouche’s research focuses on synthesizing functionalized magnetic NPs and surface modification/engineering of both tungsten disulfide nanotubes and Nano-Diamonds. These functional NPs are nontoxic/biocompatible and have a high potential as drug delivery systems, with an important imaging capability (MRI, X-ray, Fluorescence, etc.). So far, we have focused on using magnetically responsive NPs in cooperation with photodynamic therapy (PDT) drugs to achieve higher drug accumulation by magnetic targeting and, therefore, a much more effective PDT output. We also developed an effective innovative nanoscale Delivery System as an anti-Leishmania drug, which is based on cerium cation/complex-doped maghemite nanoparticles (C ·eɣ-Fe2O3NPs) that are coordinatively bound by both polyethylenemine (PEI) polymer and FDA-approved anti-leishmanial drug pentamidine. Novel surface engineering of nanodiamonds has also been innovatively discovered towards a preliminary wide range of biological and cosmetic applications. Moreover, novel functionalization of inorganic WS2 nanotubes with maghemite NPs resulted in a hybrid magnetic nanocomposite to improve anti-cancer treatment using photothermal therapy (PTT), as well as promoting nanomaterial reduced aggregation together with an additional ability for nanotube versatile second-step surface functionality/engineering. C ·eɣ-Fe O-WS-INTs PDT

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