2024 ANNUAL REPORT

| 68 | 2024 Annual Report TEM images illustrating cellular uptake of P(RGD)/Pal, Alp(50%) NCs by HCT116 colon cancer cells after incubation for 2, 5, 10, and 24 h (A–D, respectively). Green arrow (B), accumulation of NCs in the cytoplasm; yellow arrow (B), unclustered NCs; blue arrow (C), NCs in vesicles; red arrow (D), collagen fibers; M-l/M-d, live/ dead mitochondria. Scale bars represent 2 µm (left) and 500 nm (right). E) Uptake of NCs by engulfing at 2 h: NCs attached to a) outer and b, c) inner cell membrane, d) pinched off, released inside the cells, characterized by membrane (white arrow), e) empty vesicle (lysosome), and f) NCs within vesicle with membrane (white arrow). The inset shows 4× magnification. F) Schematic illustration of internalization showing NC engulfment and pinching off. Itzhaki, Ella, et al. “Tumor‐Targeted Poly (ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy–In‐vivo Study.” Advanced Therapeutics (2023): 2200337. ‏ Publications 2023 and 2024 • Sayan Ganguly, Shlomo Margel. “SurfaceEngineered Magnetic Nanoparticles (Iron Oxides) and Their Therapeutic Applications.” Magnetic Polymer Composites and Their Emerging Applications, 2024. • Natalie Mounayer, Shlomo Margel. “Engineering of Silane–Pyrrolidone Nano/ Microparticles and Anti-Fogging Thin Coatings.” Polymers, 2024. • Elisheva Sasson, Eyal Malka, Ayelet Caspi, Naftali Kanovsky, Shlomo Margel. “Engineered Thin Coatings of CrossLinked Silane Polymers with Urea Group onto Polypropylene Fabrics for Controlled Release of Thymol Against Molds in Hay.” Materials Today Chemistry, 2024. • Sayan Ganguly, Poushali Das, Seshasai Srinivasan, Amin Reza Rajabzadeh, Xiaowu Shirley Tang, Shlomo Margel. “Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release.” ACS Applied Nano Materials, 2024. • Natalie Mounayer, Taly Iline-Vul, Shlomo Margel. “Synthesis and Characterization of Durable Antifog Silane–Pyrrolidone Thin Coatings onto Polymeric Films.” Molecules, 2024. • Matan Nissim, Sivan Shoshani, Gila Jacobi, Eyal Malka, Ehud Banin, Shlomo Margel. “Engineering of New AntiBiofilm Phosphonium Thin Coatings onto Polymeric Films.” Journal of Coatings Technology and Research, 2024. • Sayan Ganguly, Shlomo Margel. “Fabrication and Applications of Magnetic Polymer Composites for Soft Robotics.” Micromachines, 2023. • Eyal Malka, Shlomo Margel. “Engineering of PVA/PVP Hydrogels for Agricultural Applications.” Gels, 2023. • Matan Nissim, Taly lline-Vul, Sivan Shoshani, Gila Jacobi, Eyal Malka, Aviv Dombrovsky, Ehud Banin, Shlomo Margel. “Synthesis and Characterization of Durable Antibiofilm and Antiviral SilanePhosphonium Thin Coatings for Medical and Agricultural Applications.” ACS Omega, 2023. • Sayan Ganguly, Shlomo Margel. “Fluorescent Quantum Dots-Based Hydrogels: Synthesis, Fabrication and Multimodal Biosensing.” Talanta Open, 2023. • Sharon Hayne, Shlomo Margel. “Thin Coating of Silica/Polystyrene Core-Shell Nano/Microparticles with Hierarchical Morphology onto Polymeric Films for Fabrication of Superhydrophobic Surfaces.” Materials Today Chemistry, 2023. • Elisheva Sasson, Omer Agazani, Eyal Malka, Meital Reches, Shlomo Margel. “Engineered Cross-Linked Silane with Urea Polymer Thin Durable Coatings onto Polymeric Films for Controlled Antiviral Release of Activated Chlorine and Essential Oils.” Journal of Functional Biomaterials, 2023. • Ella Itzhaki, Yuval Elias, Neta Moskovits, Salomon M Stemmer, Shlomo Margel. “Proteinoid Polymers and Nanocapsules for Cancer Diagnostics, Therapy and Theranostics: In Vitro and In Vivo Studies.” Journal of Functional Biomaterials, 2023. • Sayan Ganguly, Shlomo Margel. “In Situ Coatings of Polymeric Films with Core Polystyrene, Core–Shell Polystyrene/SiO2, and Hollow SiO2 Micro/Nanoparticles and Potential Applications”. ACS omega, 2023. • Naftali Kanovsky, Taly Iline-Vul, Shlomo Margel. “In-situ Design of Hierarchical Durable Silica-Based Coatings on Polypropylene Films with Superhydrophilic, Superhydrophobic and self-cleaning properties.” Results in Surfaces and Interfaces, 2023. • Sayan Ganguly, Shlomo Margel. “Bioimaging Probes Based on Magneto-Fluorescent Nanoparticles.” Pharmaceutics, 2023. • Sayan Ganguly, Shlomo Margel. “Introduction to Coatings and Surface Preparation.” Polymer-Based Nanoscale Materials for Surface Coatings, 2023. • Sayan Ganguly, Shlomo Margel. “Superhydrophobic Nanoscale Materials for Surface Coatings”. Polymer-Based Nanoscale Materials for Surface Coatings, 2023. • Ella Itzhaki, Eva Chausky‐Barzakh, Ayelet Atkins, Avital Bareket‐Samish, Salomon M Stemmer, Shlomo Margel, Neta Moskovits. “Tumor‐Targeted Poly (ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy–In‐vivo Study.” Advanced Therapeutics, 2023.

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