| 77 | Prof. Rosenbluh Michael Department of Physics Quantum Optics and Laser Spectroscopy Research Areas • Laser spectroscopy • Propagation of short pulses in homogeneously broadened media • Bulk and surface light scattering • Linear and non-linear optical properties • Heat and mass transfer during interaction of short laser pulses with optical nanocomposite materials Abstract We explore the interaction of light and matter in both the classical and quantum regimes. Applications to sensing technology, secure communications, and optical frequency standards are experimentally pursued in the lab. Closed cycle, 3.5 K, cryostat, with a built-in confocal microscope for studying quantum emitters and superconducting singlephoton detectors. Publications 2023 and 2024 • Yuri Kaganovskii, Valentin Freilikher, Michael Rosenbluh. “Photo‐Induced Evolution of Randomly Rough Surfaces of Amorphous Chalcogenide Films.” Physica Status Solidi , 2024. Prof. Ruthstein Sharon Department of Chemistry Biomolecular EPR Research Lab Research Areas • Magnetic resonance • Biophysics • Copper metabolism • Radiochemistry • Electron Paramagnetic Resonance (EPR) Spectroscopy Abstract Our work focuses on the cellular copper cycle. The knowledge gained by studying the copper cycle in eukaryotic and prokaryotic systems is then used to develop new biomarkers and therapeutic agents dependent on the copper cycle. We believe a basic understanding of the chemical and biological systems is essential for developing the next generation of biomarkers and drugs adopted in the clinic. Our group utilizes various spectroscopic (specifically EPR spectroscopy) and computational methods to resolve cellular metal transfer mechanisms in vitro and in cells at the molecular level. Moreover, when a therapeutic or diagnostic compound is developed (based on the knowledge gained in the lab), my group members perform all experiments until the mouse stage (included) in-house. The Copper cellular cycle in A. Human cell. B. In E. coli cell. Publications 2023 and 2024 • Jana Aupic, Pavlína Pokorná, Sharon Ruthstein, Alessandra Magistrato. “Predicting Conformational Ensembles of Intrinsically Disordered Proteins: From Molecular Dynamics to Machine Learning.” The Journal of Physical Chemistry Letters, 2024. • Gil Otis, Denial Aias, Ilya Grinberg, Sharon Ruthstein, Yitzhak Mastai. “Probing Chirality of Crystals using Electron Paramagnetic Resonance (EPR) Spectroscopy.” Journal of Molecular Structure, 2024. • Melanie Hirsch, Lukas Hofmann, Idan Yakobov, Shirin Kahremany, Hila Sameach, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sharon Ruthstein. “An Efficient EPR Spin-Labeling Method Enables Insights into Conformational Changes in DNA.” Biophysical Reports, 2024. • Gil Otis, Matan Oliel, Subhomoy Das, Yarden Ben Moshe, Yulia Shenberger, Sharon Ruthstein, Yitzhak Mastai. “Enantioselective Crystallization of Naturally Chiral Ag2CO3 Crystals Insights into the Influence of Chiral Additives.” Crystal Growth & Design, 2024. • Ameer Yasin, Alysia Mandato, Lukas Hofmann, Yasmin Igbaria-Jaber, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sunil Saxena, Sharon Ruthstein. “The Dynamic Plasticity of P. aeruginosa CueR Copper Transcription Factor upon Cofactor and DNA Binding.” ChemBioChem, 2024. • Yasmin Igbaria-Jaber, Lukas Hofmann, Lada Gevorkyan-Airapetov, Yulia Shenberger, Sharon Ruthstein. “Revealing the DNA Binding Modes of CsoR by EPR Spectroscopy.” ACS Omega, 2023. • Kevin Singewald, Hannah Hunter, Timothy F Cunningham, Sharon Ruthstein, Sunil Saxena. “Measurement of Protein Dynamics from Site Directed Cu (II) Labeling.” Analysis & Sensing, 2023.
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