| 81 | Temporal Organization of the Genome: Current State and Future Aims of the 4D Nucleome Project.” Molecular Cell , 2023. Prof. Shefi Orit Faculty of Engineering Neuro-Engineering and Regeneration Research Areas • Neurobiological systems development: image processing and network analysis • Tissue engineering: Developing skin grafts that enable reinnervation and regeneration • Developing devices for reagents delivery into live tissue at a microscopic resolution • Neuroprosthetic devices: Neuron-chip interface Abstract Our research aims to unveil the basic mechanisms underlying neuronal development and leverages this knowledge towards obtaining improved methods for manipulating and promoting neuronal regeneration. Neurons develop into various shapes with important implications for neuronal function and connectivity. Following nerve injuries, the process of spontaneous nerve regeneration is incomplete. Our multidisciplinary approach merges engineering, biology, nanotechnology, and material sciences at the micro and nanoscale. We analyze neuronal responses by implementing morphometric measurements, electrophysiological protocols, simulations, and bioinformatics. Moreover, we develop drug-delivery technologies to target the nervous system and key injured, diseased tissue, i.e., novel carriers and biolistic setups. 2D and 3D engineered platforms for neuronal interfaces and regeneration. Publications 2023 and 2024 • Ofek Ophir, Orit Shefi, Ofir Lindenbaum. “Classifying Neuronal Cell Types Based on Shared Electrophysiological Information from Humans and Mice.” Neuroinformatics, 2024. • Henry Hess, Allegra Coppini, Alessandro Falconieri, Oz Mualem, Syeda Rubaiya Nasrin, Marine Roudon, Gadiel Saper, Akira Kakugo, Vittoria Raffa, Orit Shefi. “Can Repetitive Mechanical Motion Cause Structural Damage to Axons?” Frontiers in Molecular Neuroscience, 2024. • Jonathan Giron, Merav Antman‐ Passig, Neta Zilony, Hadas Schori, Ido Bachelet, Orit Shefi. “DNA Origami Scaffold Promoting Nerve Guidance and Regeneration.” Biotechnology Journal , 2024. • Vittoria Raffa, Orit Shefi, Alessandro Falconieri. “Perspectives in Neuroscience: Mechanical Forces for the Modulation of Axonal Mechanics and Nerve Regeneration.” Frontiers in Molecular Neuroscience, 2024. • Dafna Rivka Levenberg, Eli Varon, Ganit Indech, Tal Ben Uliel, Lidor Geri, Amos Sharoni, Orit Shefi. “A Streptavidin–Biotin System Combined with Magnetic Actuators for Remote Neuronal Guidance.” Journal of Biological Engineering, 2023. • Elina Haimov‐Talmoud, Michal Rosenberg, Sofia Arshavsky‐Graham, Eli Varon, Orit Shefi, Ester Segal. “Biolistic Delivery of Photosensitizer‐ Loaded Porous Si Carriers for Localized Photodynamic Therapy.” Advanced Materials Technologies, 2023. • Yuxiang Zhu, Tina Kwok, Joel C Haug, Shenghan Guo, Xiangfan Chen, Weiheng Xu, Dharneedar Ravichandran, Yourka D Tchoukalova, Jeffrey L Cornella, Johnny Yi, Orit Shefi, Brent L Vernon, David G Lott, Jessica N Lancaster, Kenan Song. “3D Printable Hydrogel with Tunable Degradability and Mechanical Properties as a Tissue Scaffold for Pelvic Organ Prolapse Treatment.” Advanced Materials Technologies, 2023. • Eli Varon, Gaddi Blumrosen, Orit Shefi. ”A predictive model for personalization of nanotechnology-based phototherapy in cancer treatment.” Frontiers in Oncology, 2023. • Ganit Indech, Lidor Geri, Chen Mordechai, Yarden Ben Moshe, Yitzhak Mastai, Orit Shefi, Amos Sharoni. “Controlled Synthesis of Multifunctional DomeShaped Micro-and Nano-Structures via a Robust Physical Route for Biological Applications.” Journal of Materials Chemistry B, 2023. Prof. Shlimak Issai Department of Physics Experimental Studies of Transport Phenomena and Electronic Properties of Disordered Solids Research Areas • Doped semiconductors • Impure metals • Conducting polymers • Hopping conductivity • Magnetoresistance • Metal-insulator transition • Electron-electron interactions Abstract Prof. Issai Shlimak analyzes the repeatability of the Raman scattering (RS) spectra in monolayer and bilayer graphene films. The position and width of the RS lines and their intensity were measured in samples where a substrate-supported graphene film and the film was suspended
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