96 aim to understand how these intercellular communication networks control immunological decision-making processes, manage local and systemic inflammation or facilitate immunological tolerance. Our efforts are devoted to developing a microbiome-based, personalized therapy for human autoimmune and chronic inflammatory diseases, as well as for boosting cancer therapy. For these purposes, microscopy, next-generation genomics and molecular biology methods are used in combination with a unique gut organ culture system that we developed (Yissachar et al., Cell, 2017). This 3D system led us to discover some unexpected roles for enteric neurons in mediating microbiota-induced effector and regulatory T-cells development (Yissachar et al., Cell, 2017, Duscha et al., Cell, 2020). Schematics of the 3D gut culture system. Intact intestinal tissue is connected to input and output ports of the chamber (top), pumps controlling medium flow inside the lumen and in the external medium chamber. The entire device (bottom) contains six such chambers. Publications 2022 and 2023 • Hadar Bootz-Maoz, Ayelet Pearl, Ehud Melzer, Stephen Malnick, Efrat Sharon, Yifat Bennet, Rotem Tsentsarevsky, Shlomi Abuchatzera, Sivan Amidror, Elana Aretz, Shalhevet Azriel, Chen Gam Ze Letova, Maria Naama, Irit Shoval, Orly Yaron, Sarit Karako-Lampert, Shai Bel, Nissan Yissachar. “Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome”. Cell Reports, 2022. • Martina Sassone-Corsi, Shalhevet Azriel, Ariel Simon, Deepshika Ramanan, Adriana Ortiz-Lopez, Felicia Chen, Nissan Yissachar, Diane Mathis, Christophe Benoist. “Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts”. Proceedings of the National Academy of Sciences, 2022. • Hannah Partney, Nissan Yissachar. “Regulation of host immunity by the gut microbiota”. Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis, 2022. • Romina Monzani, Mara Gagliardi, Nausicaa Clemente, Valentina Saverio, Elżbieta Pańczyszyn, Nissan Yissachar, Marco Corazzari. “The Gut-Ex-vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of Dnbs-Induced IBDin BALB/c and C57BL/6 Mice”. Preprints, 2022. Prof. Zaban Arie President of BIU Department of Chemistry Member of BINA ex-Director of BINA Nano-Energy Center Research Areas • Solar energy • Dye Sensitized Solar Cells (DSSC) • Nanoporous wide band-gap semiconductor electrodes, single material and core-shell systems • Nanosize wide band-gap semiconductors with controlled properties via surface control • Low cost spectral splitting for multibandgap photovoltaics • Interdigitated organic/inorganic nanosize layers towards the development of low cost “plastic” solar cells and smart polymers Abstract The Cahen-Zaban group studies (opto) electronic materials, esp. for Photovoltaics. A major tool is combinatorial material science to answer renewable energy’s need for new materials, i.e., to explore compounds with unique characteristics with current focus on halide perovskites and charge-selective metal oxides. Further interests are in Biomolecules, esp. proteins as electronic materials for future bioelectronics. Work-flow diagram of the combinatorial material science scheme. Prof. Zadok Avi Faculty of Engineering Member of BINA Nano-Photonics Center Research Areas • Fiber optics sensing • Silicon Photonics • Nonlinear Optics • Wafer Bonding • Optical Communication Abstract Fiber optics and integrated photonic devices The research group of Prof. Zadok is working on two main themes: Optical fibers, and photonic integrated circuits. On the fibers side, the group focuses on sensor applications: the use of optical fibers for the mapping of quantities of interest such as temperature, strain, and various chemicals. The group is pioneering a new sensor concept based on the combination of light and sound waves, which supports measurements outside the fiber boundaries where light cannot reach. On the devices side, the group specializes in photonic integrated circuits in silicon and glass, for data communication and sensing purposes. Examples include multiplexers for dense wavelength division communication, and narrowband radio-frequency filters. Here too, the group relies on interactions between light and sound waves to achieve performance that is unattainable using light alone.
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